William S Bush – Assessing the Genetic Basis of Drug Response

By definition pharmacogenomic traits have an underlying genetic basis. Nevertheless, accurately estimating the heritability of drug response is important for designing studies and knowing how much genetic variation can—or has—been explained. Unlike most quantitative and qualitative traits, however, response to treatment has two unique, complicating factors: it is a gene-drug interaction and the outcome is often in terms of time-to-event. Here I will present and apply methods that address these two aspects when estimating the genetic basis (or heritabiiity) of pharmacogenomic traits.