Research Center for Molecular Medicine of the Austrian Academy of Sciences, Austria
Christoph Bock is a principal investigator at the Research Center for Molecular Medicine of the Austrian Academy of Sciences, a guest professor at the Medical University of Vienna’s department for laboratory medicine and an adjunct group leader at the Max Planck Institute for Informatics. His research group focuses on medical epigenomics, working on the rational design of epigenetic cancer therapies. Previous appointments include the Max Planck Institute for Informatics (PhD studies) and the Broad Institute of MIT and Harvard (postdoctoral training). He has been awarded an Otto Hahn Medal by the Max Planck Society for pioneering work in computational epigenetics.
The relevance of epigenomics for personalized medicine
In my presentation, I will summarize the role of next generation sequencing for personalized medicine and highlight the relevance of bioinformatic and biostatistical methods for interpreting the vast amount of genome, epigenome and transcriptome data that are being generated at CeMM and at many genomics institutes world-wide. The talk will also discuss our ongoing work with the European BLUEPRINT project consortium (http://blueprint-epigenome.eu/) aimed at establishing comprehensive epigenome maps of hematopoietic cell types and various types of leukemia cells. I will conclude by outlining an integrated computational/experimental approach toward rational design of epigenetic combination therapies (Bock and Lengauer 2012 Nature Reviews Cancer), which we pursue in collaboration between the CeMM Research Center for Molecular Medicine and the Medical University of Vienna.