Knut Rudi

Norwegian University for Life Sciences, Norway


Microbiome-genome interactions and human disease: an introduction and latest methodological developments

The interface hypothesis in explaining host-bacterial interactions in the human gut

Our gut microbiota is tremendously complex, outnumbering the host cells by a factor of ten and the number of genes by a factor of one hundred. The gut microbiota serves the main functions of extracting energy from the food, production of vitamins and other (essential) biomolecules, in addition to protection towards pathogens. However, despite major efforts we do still not know the basic mechanisms for host-bacterial interactions in the gut. We have therefore recently proposed the interface hypothesis, advocating the importance of positive host selection for mutualistic gut bacteria. I will present details about the hypothesis, and how it is supported from the current knowledge about the human gut microbiota.